Effects of Oral Collagen Drinks on Human Skin

TCI

Status: Enrolling

Conditions: Skin Condition; Collagen Synthesis

Treatments: Dietary Supplement: MAXI Collagen Drink; Dietary Supplement: Collagen Drink; Dietary Supplement: MAXI Collagen Drink_High dose

Study type: Interventional

Funder types: Industry

Identifiers

NCT07605871

SECCR2025-254

Details and patient eligibility

About

The objective of this study is to evaluate the effect of oral collagen drink and MAXI collagen drink on human skin condition improvement.

Full description

This study is a single-center, double-blinded, parallel human trial designed to evaluate the skin beauty effect of oral collagen drink and MAXI collagen drink.

Healthy adult participants aged 18-60 years will be enrolled. Participants will be informed to consume test samples daily for 4 consecutive weeks. Skin measurement and self-assessment questionnaires will be conducted at baseline (before intake), after 1 week, and 4 weeks of consumption.

Enrollment: 99 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy Chinese subjects aged 18 to 60 years, both male and female.
• Wrinkle Severity: Crow's feet graded 2-4; under-eye fine lines graded 2-5; nasolabial folds graded 1-3.
• Presence of facial skin laxity and sagging.
• Ability to undergo skin examinations and pre-treatment in the designated test areas.
• Ability to understand the trial process, participate voluntarily, and sign a written Informed Consent Form (ICF).

Exclusion criteria

• Pregnant or lactating women, or those planning to become pregnant in the near future.
• Highly sensitive constitution, history of allergic diseases, or history of allergies to cosmetics.
• Presence of skin diseases (e.g., psoriasis, eczema, atopic dermatitis, severe acne) or other chronic systemic diseases.
• Skin conditions in the test area such as birthmarks, hyperpigmentation, inflammation, scars, nevi (moles), or hypertrichosis (excessive hair).
• Use of anti-inflammatory drugs (e.g., oral or topical corticosteroids) within the past month.
• Use of cosmetics or other products with similar efficacy within the past 2 weeks.
• Participation in other human clinical trials for cosmetics within the past month.
• Any other conditions deemed unsuitable for participation based on clinical assessment.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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99 participants in 3 patient groups

Collagen Drink

Active Comparator group

Description:

oral intake 5 g collagen daily

Treatment:

Dietary Supplement: Collagen Drink

MAXI Collagen Drink

Experimental group

Description:

oral intake 15 mL MAXI collagen daily (equivalent to 5 g of deep hydrolyzed collagen net weight)

Treatment:

Dietary Supplement: MAXI Collagen Drink

MAXI Collagen Drink_High dose

Experimental group

Description:

oral intake 30 mL MAXI collagen daily (equivalent to 10 g of deep hydrolyzed collagen net weight)

Treatment:

Dietary Supplement: MAXI Collagen Drink_High dose