Effects of Oral Fruit Concentrate Supplementation on Cardiometabolic Parameters.

University of Central Lancashire

Status: Completed

Conditions: Metabolic Syndrome

Treatments: Dietary Supplement: Fruit concentrate - either cherry or blueberry

Study type: Interventional

Funder types: Other

Identifiers

NCT04177238

Cherry/ blueberry concentrate

Details and patient eligibility

About

Cardiovascular disease, type 2 diabetes mellitus and associated diseases combined are the leading health burden and cause of mortality worldwide; therefore, the necessity for an intervention is paramount. Dietary interventions to improve cardiometabolic health are highly sought after as they possess less risk than pharmacological drugs. Anthocyanins, found in high quantities in both tart cherries and blueberries are powerful antioxidants, that are potentially capable of improving cardiometabolic dysfunction. However, to date, no research has explored the cardiometabolic responses to tart cherry and blueberry supplementation.

Therefore, the primary purpose of the proposed investigation is to test the ability of oral tart cherry and blueberry supplementation to improve cardiometabolic parameters in healthy individuals.

Enrollment: 45 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• 18 years of age and above
• Non-smoker
• BMI < 30
• Able to give informed consent

Exclusion criteria

• Pregnancy
• Diabetes or any other metabolic/ uncontrolled hypertensive conditions
• Food allergies to cherries or blueberries
• Habitual consumption of blueberries/ cherries and/or blueberry/ cherry products
• Not regularly taking medication or antioxidant supplements

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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45 participants in 3 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Identical in taste and colour to the supplement juice, but with no anthocyanin content

Treatment:

Dietary Supplement: Fruit concentrate - either cherry or blueberry

Cherry juice

Experimental group

Description:

30 mL of tart juice concentrate, which will be diluted with 100 mL of water - taken twice per day,

Treatment:

Dietary Supplement: Fruit concentrate - either cherry or blueberry

Blueberry

Experimental group

Description:

30 mL of tart juice concentrate, which will be diluted with 100 mL of water - taken twice per day,

Treatment:

Dietary Supplement: Fruit concentrate - either cherry or blueberry