Effects of Oxytocin on Hemodynamics in Patients Undergoing Laparoscopic Myomectomy

Yangzhou University

Status: Unknown

Conditions: Laparoscopic Surgery; Hemodynamic Monitoring; Oxytocin

Treatments: Drug: Oxytocin

Study type: Interventional

Funder types: Other

Identifiers

NCT04109339

20190501

Details and patient eligibility

About

This project will study the effect of oxytocin on hemodynamics in patients undergoing laparoscopic myomectomy, and how to prevent and manage such hemodynamic changes effectively.It provides a reference for the rational use of oxytocin in clinical practice, which can not only effectively contract the uterus and reduce bleeding, but also reduce the influence on hemodynamics.

Enrollment: 80 estimated patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• General anesthesia for gynecological laparoscopic surgery,ASA I~III

Exclusion criteria

• Oxytocin use contraindications

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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80 participants in 4 patient groups

group 1 with no oxytocin

No Intervention group

group 2 with oxytocin 10 U IM + oxytocin 10 U IV

Experimental group

Treatment:

Drug: Oxytocin

group 3 with oxytocin 20 U IM + oxytocin 0 U IV

Experimental group

Treatment:

Drug: Oxytocin

group 4 with oxytocin 0 U IM + oxytocin 20 U IV

Experimental group

Treatment:

Drug: Oxytocin