Effects of Ozone Therapy as an Adjunct to Periodontal Treatment

TC Erciyes University

Status: Completed

Conditions: Periodontitis

Treatments: Device: Ozone application with the Ozonytron XL device

Study type: Interventional

Funder types: Other

Identifiers

NCT03652558

Tasdemir

Details and patient eligibility

About

This randomized, placebo controlled, split-mouth clinical study trial evaluates the effects of Ozone therapy on clinical and biochemical parameters. Total of 20 participants completed the study . Periodontal parameters were evaluated at baseline and 3 months following periodontal therapy. All participants were treated non-surgically. Topical gaseous ozone was applied into periodontal pockets. Gingival crevicular fluid pentraxin-3 (PTX-3), interleukin-1β (IL-1β) and high sensitivity C-reactive protein (Hs-CRP) were evaluated.

Full description

Ozone therapy (OT) is very popular in medicine. Especially it use for wound healing and antibacterial properties. This randomized, placebo controlled, randomized split-mouth clinical study evaluates the effects of ozone therapy on clinical and biochemical parameters. Total of 20 participants completed the study (10 males, 10 females). Periodontal parameters, including plaque index (PI), gingival index (GI), probing depth (PD), percentage of bleeding on probing, percentage of pockets deeper than 5 mm and clinical attachment level (CAL), and percentage of ≥3 mm clinical attachment level. Periodontal parameters were evaluated at baseline and 3 months following periodontal therapy. All participants were treated non-surgically. Topical gaseous ozone was applied into periodontal pockets twice a week for 2 weeks during active periodontal therapy. Gingival crevicular fluid pentraxin-3 (PTX-3), interleukin-1β (IL-1β) and high sensitivity C-reactive protein (Hs-CRP) were evaluated.

Enrollment: 20 patients

Sex: All

Ages: 18 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 to 64 years of age
• Generalized chronic periodontitis(Armitage, 1999)
• Systemically healthy
• More than 20 teeth (excluding third molars)

Exclusion criteria

• Periodontal treatment within 6 months
• Antibiotic use within the previous 3 months
• Pregnancy and lactation
• Past or current smoking and alcohol consumption
• Contraindications for OT
• Patients with class II and III furcation defects(Staffileno, 1969)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 2 patient groups

ozone group

Experimental group

Description:

topical gaseous ozone was applied into periodontal pockets during active periodontal therapy

Treatment:

Device: Ozone application with the Ozonytron XL device

non-ozone group

No Intervention group

Description:

Only active periodontal therapy was performed