Effects of Palmar Cooling on the Human Immune System

Stanford University

Status: Completed

Conditions: Human Immune Response

Treatments: Other: Muscle Temperature Control

Study type: Interventional

Funder types: Other

Identifiers

NCT07215338

73909

Details and patient eligibility

About

This is a research study on human exercise that will investigate the immune system response post-exercise and how it relates to Delayed Onset Muscle Soreness (DOMS), and possible causes for DOMS.

Blood draws (10mL) will be obtained at 5 timepoints: Baseline before intervention, day of exercise immediately following exercise, and post-exercise days 1, 2 and 4.

Point of care lactate levels obtained before and after exercise.

Subjective pain scores recorded daily starting immediately after after exercise.

Enrollment: 22 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

- Ability to perform two arm bicep curl of at least 35 lb as 1 repetition maximum

Exclusion criteria

• Autoimmune disease
• Steroid use
• On current immune-modifying treatment

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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22 participants in 2 patient groups, including a placebo group

30 degree celsius

Placebo Comparator group

Description:

Participants will be asked to complete 10 sets of bicep curls to muscle failure with 3 minute rests between sets. The placebo participants will put their palms on a water perfused pad between sets and following the last set. The pads will be perfused with 30 degree C water.

Treatment:

Other: Muscle Temperature Control

14 degree celsius

Experimental group

Description:

Participants will be asked to complete 10 sets of bicep curls to muscle failure with 3 minute rests between sets. For the experimental participants they will rest their palms on a water perfused pad during each 3 minute rests and also following the last set of curls. The pads will be perfused with 12 - 14 degrees Centigrade water. curls to muscle failure.Participants will use the palmar temperature control device set to 14 degree celsius for 3 minutes. between 10 sets of bicep curls matched to control counterpart.

Treatment:

Other: Muscle Temperature Control