Effects of Panax Ginseng and Salvia Miltiorrhiza Supplementation on Vascular Function

National Taiwan University

Status: Unknown

Conditions: Healthy

Treatments: Behavioral: Eccentric exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT02007304

201112068MIB

Details and patient eligibility

About

The purpose of is to determine the preventive effects of Chinese herb supplement with panax ginseng and salvia miltiorrhiza prior to eccentric resistance exercise on arterial stiffness and vascular reactivity by using a double-blind randomized control design and to examine the effects of a 12-week progressive eccentric resistance exercise training on arterial elasticity and vascular reactivity, and whether a long-term supplementation would ameliorate arterial stiffening effects elicited by exercise-induced inflammation and improve endothelial function.

Enrollment: 48 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

-Healthy sedentary adults

Exclusion criteria

• obesity (BMI >30 kg/m2)
• smoking within past six months
• hypertension (high blood pressure >140/90 mmHg)
• personal history of diabetes (fasting blood glucose >126 mg/dL), heart disease, or other cardiovascular problems
• orthopedic injury that may prevent him or her from completing the exercise
• the use of over-the-counter supplements or vitamins

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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48 participants in 2 patient groups, including a placebo group

Herbs

Experimental group

Description:

participants assigned to experimental arm will take 300mg panax ginseng and 300mg salvia miltiorrhiza extracts in capsules for 12 weeks along with eccentric exercise training

Treatment:

Behavioral: Eccentric exercise training

Placebo

Placebo Comparator group

Description:

parcipants in this group will take placebo capsule containing microcrystalline cellulose

Treatment:

Behavioral: Eccentric exercise training