Effects of Parenteral and Enteral Nutrition on Skeletal Muscle Genomics

Göteborg University

Status: Completed

Conditions: Muscle Loss

Treatments: Other: Control; Dietary Supplement: Enteral nutrition; Dietary Supplement: Parenteral nutrition (PN)

Study type: Interventional

Funder types: Other

Identifiers

NCT05080816

MB3

Details and patient eligibility

About

The study investigates effects related to muscle protein metabolism at provision of Parenteral or enteral nutrition

Full description

Randomized study investigation alterations in muscle protein metabolism at provision of parenteral or enteral (oral drink) nutrition. The study uses a genomic/transcriptomic/proteomic approach to evaluate factors related to activation of skeletal muscle protein synthesis and protein degradation. Patients scheduled for major gastrointestinal surgery are included. Muscle specimens are collected during surgery.

Enrollment: 39 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Major gastrointestinal surgery.
• Assumed need of post-operative nutrition support.

Exclusion criteria

• Insulin dependent diabetes.
• Steroid medication.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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39 participants in 3 patient groups, including a placebo group

Parenteral nutrition

Active Comparator group

Description:

Overnight infusion of parenteral nutrition. Supplied as all-in-one-bag format. Infusion rate of 0.2 g N/kg/day.

Treatment:

Dietary Supplement: Parenteral nutrition (PN)

Enteral nutrition

Active Comparator group

Description:

Oral nutrition drink. 2 \* 200 ml on the night before operation. 1\* 200 ml on the morning of operation day.

Treatment:

Dietary Supplement: Enteral nutrition

control

Placebo Comparator group

Description:

Overnight infusion of crystalloid fluid (Ringer acetate) infused at the same rate (ml/kg) as intervention PN

Treatment:

Other: Control