Effects of Parmigiano Reggiano on Skeletal Muscle Damage in Older Adults

University of Padova

Status: Unknown

Conditions: Muscle Soreness; Old Age; Atrophy; Inflammatory Response

Treatments: Dietary Supplement: Parmigiano Reggiano; Dietary Supplement: Whey Protein

Study type: Interventional

Funder types: Other

Identifiers

NCT04872374

PaRMA.1

Details and patient eligibility

About

Aging is associated with the loss of muscle mass and function (sarcopenia) and reduced tissue regenerative capacity.

Eccentric exercise (ECC) is a model of RET that can be used with the elderly, due to the ability of the muscle to combine high muscle strength production with low energy cost. ECC contractions are significantly more damaging to the muscles and produce greater muscle strength, for these reasons there is a greater risk of inducing muscle damage before the muscle is able to adapt.

Parmigiano Reggiano (PR) has some peculiar bromatological characteristics. The proteins contained in it, and in particular the potentially bioactive peptide sequences, can rapidly provide the amino acids necessary to promote muscle growth and repair during exercise. Furthermore, PR can be an important source of fatty acids, of which a significant amount of short-chain fatty acids (SCFA) which are known to have important clinical effects on body composition and metabolic health and can have a systemic anti-inflammatory effect.

Therefore, the central hypothes is that PR consumed during RET can provide more energy substrates and improve muscle recovery. To date, no studies have studied its function on recovery from exercise nor in the elderly.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age >60 years old or >18 and < 30 years old
• BMI >18 and <30 kg/m2
• stable body weight in the past 3 months
• valid medical certifacate for practice of physical activity

Exclusion criteria

• diabetes or pre-diabetes as for ADA guidelines
• chronic diseases (cardiovascular, liver, respiratory, cancer, etc)
• acute inflammatory status
• regular practice of intense physical activity (>2 sessions/week)
• treatment with steroids in the past 3 months
• regular use of >50g/die of Parmigiano Reggiano

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Young adults

Experimental group

Description:

participants will perform an eccentric exercise bout after 10 days of dietary supplementation

Treatment:

Dietary Supplement: Whey Protein

Dietary Supplement: Parmigiano Reggiano

Older adults

Active Comparator group

Description:

participants will perform an eccentric exercise bout after 10 days of dietary supplementation

Treatment:

Dietary Supplement: Whey Protein

Dietary Supplement: Parmigiano Reggiano