Effects of Peanut Intake on Cognitive Functions

Loma Linda University (LLU)

Status: Completed

Conditions: Inflammation; Cognition

Treatments: Other: Habitual Diet; Dietary Supplement: Peanuts

Study type: Interventional

Funder types: Other

Identifiers

NCT05532007

5210436

Details and patient eligibility

About

The study will test the effects of Peanuts on task-related brain activation and cognitive functions in older adults with memory complaints.

Full description

The purpose of the study is to determine the effects of peanuts on cognitive performance and task-related brain activation on functional magnetic resonance imaging (fMRI) in older adults. The specific aim of the study is to explore the neuroprotective effects of a peanut-enriched diet (2-3 oz of peanuts to replace 20% of the total energy of the habitual diet) for 12 weeks compared to a peanut-excluded habitual diet in elderly men and women with increased risk for CVD and self-reported memory complaints. The study population is older adults 60-80 years in age.

Enrollment: 30 patients

Sex: All

Ages: 60 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non-demented elderly between 60-80 years of age
• Self-reported memory complaints
• Two cardiovascular risk factors
• Stable weight for at least 6 months prior to recruitment

Exclusion criteria

• Peanut allergy
• Smoker
• Endocrine, metabolic and neuropsychological disorders
• Ineligible to get an MRI
• Consuming more than 3 servings/week of nuts including peanuts

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups

Peanut Group

Active Comparator group

Description:

Peanuts: 2-3 ounces per day to replace 20% of daily energy intake

Treatment:

Dietary Supplement: Peanuts

Control Group

Active Comparator group

Description:

Habitual diet abstain from eating peanuts

Treatment:

Other: Habitual Diet