Effects of Pectin Supplementation in Diarrhea-predominant Irritable Bowel Syndrome

Nanjing PLA General Hospital

Status and phase: Completed; Phase 3

Conditions: Irritable Bowel Syndrome

Treatments: Dietary Supplement: maltodextrin; Dietary Supplement: Pectin

Study type: Interventional

Funder types: Other

Identifiers

NCT02270268

2011NLY073

Details and patient eligibility

About

The purpose of this study is to investigate the effect of pectin, a kind of soluble dietary fiber, on clinical symptoms, gut microbiota and the immune status in patients with diarrhea-predominant irritable bowel syndrome

Full description

Patients were randomized to receive either pectin or placebo. Treatment consisted of 6 weeks supplementation with pectin (fiber group) or placebo (maltodextrin). We evaluated the clinical symptoms, gut microbiota and the immune markers in two groups.

Enrollment: 114 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients(age≧18y)
• Admitted for diarrhea-predominant irritable bowel syndrome

Exclusion criteria

• Mental disorders
• Cancer
• Inflammatory bowel disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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114 participants in 2 patient groups, including a placebo group

pectin

Experimental group

Description:

a kind of soluble dietary fiber

Treatment:

Dietary Supplement: Pectin

Placebo

Placebo Comparator group

Description:

maltodextrin

Treatment:

Dietary Supplement: maltodextrin