Effects of PEEP on Intracranial and Intraocular Pressure in Robot-assisted Laparoscopic Radical Prostatectomy

Yonsei University Health System (YUHS)

Status: Unknown

Conditions: Prostate Cancer

Treatments: Procedure: PEEP group; Procedure: ZEEP group

Study type: Interventional

Funder types: Other

Identifiers

NCT03031613

3-2016-0263

Details and patient eligibility

About

To investigate the effects of positive end-expiratory pressure (PEEP) on the intracerebral pressure (ICP) and intraocular pressure (IOP) in patients undergoing robot assisted laparoscopic radical prostatectomy (RALRP)

Full description

Application of PEEPmay reduce pulmonary complication following RALRP. Meanwhile, it may increase ICP and IOP, which has been debated for decades. Moreover, Trendelenburg position and pneumoperitoneum, which are mandatory for RALRP, may augment elevation of ICP and IOP. This study aims to investigate the effects of PEEP on the ICP and IOP in patients undergoing RALRP.

Enrollment: 50 estimated patients

Sex: Male

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients undergoing robotic-assisted laparoscopic radical prostatectomy

Exclusion criteria

• History of opthalmic disease or surgery
• History of brain disease or surgery
• Known ICP elevation
• Known IOP elevation
• Presence of lung bullae on chest x-ray
• History of pneumothorax

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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50 participants in 2 patient groups

PEEP group

Experimental group

Description:

Application of 5 cmH2O PEEP during mechanical ventilation

Treatment:

Procedure: PEEP group

ZEEP group

Active Comparator group

Description:

No application of PEEP during mechanical ventilation

Treatment:

Procedure: ZEEP group