Effects of PEP on IC During IT in Patients With COPD

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Status: Terminated

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Device: PEP-10; Device: PEP-1

Study type: Interventional

Funder types: Other

Identifiers

NCT03657082

PEP-IC

Details and patient eligibility

About

This study will investigate the effects of positive expiratory pressure (PEP) on hyperinflation in patients with chronic obstructive pulmonary disease (COPD). Inspiratory capacity (IC) is the primary outcome

Full description

This is a cross-over intervention assessing the effect of PEP on IC and dyspnea in patients with COPD performing an interval training (IT) session.

IC will be measured before, during and immediately after the IT session. Each participant will receive perform IT sessions including either the use of a PEP of 10 cmH2O or a PEP of 1 cmH2O. The effects on IC and dyspnea on both PEP levels will be assessed.

Enrollment: 1 patient

Sex: All

Ages: 45 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stable COPD since 1 month at least
• Able to understand the instructions

Exclusion criteria

• COPD with a forced expiratory volume at one second > 80% of predicted values
• In exacerbation
• Orthopedic of neurological condition likely to interfere with the experimentation
• Contraindication to perform exercise

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

1 participants in 2 patient groups

Arm A

Experimental group

Description:

In this arm, patients will receive the experimental condition first, then the sham condition

Treatment:

Device: PEP-10

Device: PEP-1

Arm B

Experimental group

Description:

In this arm, patients will receive the sham condition first, then the experimental condition

Treatment:

Device: PEP-10

Device: PEP-1