Effects of Peppermint Oil in Mild-moderate Hypertension.

University of Central Lancashire

Status: Enrolling

Conditions: Hypertension

Treatments: Other: Placebo; Dietary Supplement: Peppermint oil

Study type: Interventional

Funder types: Other

Identifiers

NCT05561543

Peppermint oil hypertension

Details and patient eligibility

About

Cardiovascular and associated hypertensive diseases are the leading health burden and cause of mortality worldwide; therefore, the necessity for effective interventions is paramount. Dietary interventions to improve cardiovascular health are highly sought after as they possess less risk and financial burden than pharmacological drugs. Our previous randomized trial has shown that oral peppermint can improving systolic blood pressure and other cardiovascular/ blood lipids in healthy individuals. However, to date, no research has explored this using a placebo randomized intervention in patients with hypertension.

Therefore, the primary purpose of the proposed investigation is to test the ability of oral peppermint oil supplementation to improve cardiometabolic parameters in participants with mild-moderate hypertension.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Aged from 18-65 years
2. Systolic blood pressure 120 to 139 mmHg
3. Not taking prescribed medicine for blood pressure management
4. have the ability to complete written questionnaires independently
5. Able to provide informed consent

Exclusion criteria

1. Diagnosed with diabetes mellitus and/ or coronary heart disease
2. Pregnant and lactating women
3. Allergy to peppermint
4. Habitual consumption of peppermint products
5. Regular consumption of antioxidant supplements

(5) Body mass index larger than 40.0 kg/m2 (6) Current enrolment in other clinical trials of other external therapies

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Identical in taste and colour to the supplement juice, but with no peppermint content.

Treatment:

Other: Placebo

Peppermint oil

Experimental group

Description:

50 uL of peppermint oil, which will be diluted with 100 mL of water - taken twice per day.

Treatment:

Dietary Supplement: Peppermint oil