Effects of Perioperative Administration of Intravenous Lidocaine in Children Operated on for Acute Generalized Peritonitis

Université NAZI BONI

Status: Not yet enrolling

Conditions: Postoperative Pain

Treatments: Drug: Serum saline intravenous; Drug: Lidocaine intravenous

Study type: Interventional

Funder types: Other

Identifiers

NCT06051630

INSSA 3

Details and patient eligibility

About

Intravenous administration of lidocaine perioperatively after laparotomy for peritonitis could be an interesting alternative by reducing the duration of postoperative ileus, the intensity of pain and the patient's hospital stay, as well as the cost of management in our context of lack of financial, technical and human resources, hence the present study.

Enrollment: 62 estimated patients

Sex: All

Ages: 6 to 15 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All patients aged 6 to 15, Classified according to the American Society of Anaesthesiologists (ASA) (I, II and III) admitted for peritonitis and whose parents have given informed consent

Exclusion criteria

• State of shock
• Severe renal insufficiency (creatinine clearance less than 30 ml/min)
• History of allergy to lidocaine
• Refusal to participate in the study

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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62 participants in 2 patient groups, including a placebo group

Lidocaine group

Experimental group

Description:

The group will receive 1.5 mg/kg lidocaine 2% bolus, followed by a continuous electric syringe dose of 1.5 mg/kg/hour intraoperatively, then 1.5 mg/kg/hour during the first 24 hours postoperatively

Treatment:

Drug: Lidocaine intravenous

Saline group

Placebo Comparator group

Description:

The control group will receive an equivalent volume of saline: the volume of saline to be administered will be obtained by considering the dose of lidocaine 2% that the patient would have received if he/she had been in the interventional group.

Treatment:

Drug: Serum saline intravenous