Effects of Perioperative Immunonutrition in Patients With Head and Neck Cancer

TC Erciyes University

Status

Completed

Conditions

Nutrition, Healthy

Head and Neck Cancer

Treatments

Dietary Supplement: Experimental (Immunonutrition) Group

Dietary Supplement: Active Comparator Group ( Standard enteral nutrition)

Study type

Interventional

Funder types

Other

Identifiers

NCT06318221

06156930

Details and patient eligibility

About

A prospective randomized controlled study compared the effects of perioperative immunonutrition and standard enteral nutrition (EN) on postoperative short-term outcomes of patients with head and neck (HNC).

Five days before surgery and the postoperative day 10, immunonutrition support was given to the intervention group (n=17), and standard EN support was given to the control group (n=17). Body analyses were made, food consumption records were taken, NRS-2002 and quality of life scales were applied, and biochemical parameters were recorded.

Enrollment

34 patients

Sex

All

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Clinical diagnosis of squamous cell carcinoma of the oral cavity, oropharynx, larynx or hypopharynx who will undergo surgery,
who agree to receive standard EN or immunonutrition before surgery,
those between the ages of 18-75,
those with normal hematopoietic (absolute neutrophil count >1.8x109/L, hemoglobin level ≥9 g/dL) hepatic and renal function

Exclusion criteria

Patients receiving neoadjuvant chemotherapy or radiotherapy to the head and neck region;
Received EN support before the study
have an active infection, any autoimmune, renal or hepatic disease, malabsorption, type 1 diabetes or mental illness
taking vitamin-mineral supplements and immunosuppressive treatment,
Morbidly obese (BMI ≥40 kg/m2), HIV positive, pregnant and breastfeeding individuals