Effects of Phenolic Acids on Endothelial Function

N

Nestlé

Status

Completed

Conditions

Healthy

Treatments

Other: Phenolic acids

Study type

Interventional

Funder types

Industry

Identifiers

NCT01772784
11.36.NRC

Details and patient eligibility

About

Epidemiological studies suggest dietary (poly) phenols decrease the risk of death from cardiovascular diseases. (Poly)phenol-rich foods include fruits and vegetables as well as tea, coffee, red wine, and chocolate. The aim of the present study is to investigate whether endothelial function is altered by ingestion of phenolic acids. Moreover, the investigators will evaluate the effect of phenolic acids on blood pressure and platelet adhesion.

Enrollment

24 patients

Sex

Male

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy
  • males
  • Smokers

Exclusion criteria

Any food allergy

  • Abnormal blood pressure defined as follow: systolic <100 or >160 mmHg and diastolic <50 or >100mmHg
  • Regular consumption of medication within 2 months before the study inclusion
  • Caffeine intake 1 day before screening measurements (and 1 day before each visit),
  • Any intake of multivitamin-tablets and other supplemental compounds 10 days before the study start and throughout the study.
  • Excessive alcohol intake defined as > 280 g per week

Trial design

24 participants in 4 patient groups, including a placebo group

phenolic acids
Experimental group
Description:
Maltodextrine + Phenolic acids
Treatment:
Other: Phenolic acids
placebo
Placebo Comparator group
Description:
Maltodextrine
Treatment:
Other: Phenolic acids
phenolic acid
Experimental group
Description:
Maltodextrine + Phenolic acids
Treatment:
Other: Phenolic acids
polyphenol
Active Comparator group
Treatment:
Other: Phenolic acids

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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