Effects of Phenolic Acids on Endothelial Function

Nestlé

Status: Completed

Conditions: Healthy

Treatments: Other: Phenolic acids

Study type: Interventional

Funder types: Industry

Identifiers

NCT01772784

11.36.NRC

Details and patient eligibility

About

Epidemiological studies suggest dietary (poly) phenols decrease the risk of death from cardiovascular diseases. (Poly)phenol-rich foods include fruits and vegetables as well as tea, coffee, red wine, and chocolate. The aim of the present study is to investigate whether endothelial function is altered by ingestion of phenolic acids. Moreover, the investigators will evaluate the effect of phenolic acids on blood pressure and platelet adhesion.

Enrollment: 24 patients

Sex: Male

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• males
• Smokers

Exclusion criteria

Any food allergy

• Abnormal blood pressure defined as follow: systolic <100 or >160 mmHg and diastolic <50 or >100mmHg
• Regular consumption of medication within 2 months before the study inclusion
• Caffeine intake 1 day before screening measurements (and 1 day before each visit),
• Any intake of multivitamin-tablets and other supplemental compounds 10 days before the study start and throughout the study.
• Excessive alcohol intake defined as > 280 g per week

Trial design

24 participants in 4 patient groups, including a placebo group

phenolic acids

Experimental group

Description:

Maltodextrine + Phenolic acids

Treatment:

Other: Phenolic acids

placebo

Placebo Comparator group

Description:

Maltodextrine

Treatment:

Other: Phenolic acids

phenolic acid

Experimental group

Description:

Maltodextrine + Phenolic acids

Treatment:

Other: Phenolic acids

polyphenol

Active Comparator group

Treatment:

Other: Phenolic acids