Effects of Physical Activity on the Brain in Impaired Glucose Tolerance (IGT)

Charité University Medicine Berlin

Status and phase: Completed; Phase 4

Conditions: Impaired Glucose Tolerance

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT01219231

exercise_neuromod

Details and patient eligibility

About

The researchers will investigate whether exercise could provide positive effects on general brain functions in elderly people with impaired glucose tolerance.

Full description

The age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as Alzheimer's disease are a growing public-health concern with devastating effects.

Referring to animal data, empirical studies, and pilot human trials, exercise should improve cognitive functions such as learning and memory. To test this hypothesis, the researchers study general brain functions in elderly subjects (50-80 years old) with impaired glucose tolerance during a short term exercise program.

Enrollment: 46 estimated patients

Sex: All

Ages: 50 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• subjects with impaired glucose tolerance
• 50-65 years old
• moderate to heavy weight (BMI 25-35)
• must be able to do exercise intervention

Exclusion criteria

• diabetes
• younger than 50 years
• BMI < 25
• psychiatric medication
• severe disease
• MMSE < 26
• severe cardiovascular disorders

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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46 participants in 2 patient groups, including a placebo group

Exercise

Experimental group

Treatment:

Behavioral: Exercise

Placebo

Placebo Comparator group

Treatment:

Behavioral: Exercise