Effects of Physical Activity on the Brain in Parkinson's Disease (PD)

Charité University Medicine Berlin

Status: Completed

Conditions: Parkinson's Disease

Treatments: Behavioral: stationary bike exercise; Behavioral: aerobic

Study type: Interventional

Funder types: Other

Identifiers

NCT01741584

PA_memory_01

Details and patient eligibility

About

The aim of the study is to investigate whether exercise improves cognitive and motor functions in Parkinson's disease. To test this hypothesis, the researchers study general brain functions in subjects with PD during a 6-months exercise program.

Enrollment: 20 estimated patients

Sex: All

Ages: 35 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• UPDRS <15
• L-DOPA responsive
• <5 yrs since diagnosis

Exclusion criteria

• severe other diseases
• MMSE < 26
• treatment with psychiatric medication

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

20 participants in 2 patient groups, including a placebo group

stationary bike exercise

Experimental group

Description:

6 months of exercise (60% of anaerobic threshold)

Treatment:

Behavioral: stationary bike exercise

aerobic

Placebo Comparator group

Description:

6 months of exercise \<30% anaerobic threshold

Treatment:

Behavioral: aerobic