Effects of Physical Activity on Weight Loss and Weight Maintenance in Obese Adults - Three Year Follow-up Study (LILA)

University of Oulu

Status: Completed

Conditions: Weight Loss; Healthy Obesity, Metabolically; Physical Activity; Obesity

Treatments: Behavioral: Lifestyle modification

Study type: Interventional

Funder types: Other

Identifiers

NCT03861754

147/2006

Details and patient eligibility

About

Objective To study if exercise added to weight loss treatment at the beginning of the weight loss intervention or at 6 months could sustain the weight loss achieved or give extra boost for weight reduction.

Design 36-month, 4-group parallel, randomized trial.

Setting Oulu, Finland.

Participants 120 obese adults (body mass index ≥ 30).

Intervention Participants were randomly assigned to behavioural modification (iBM) (n = 30), behavioural modification + exercise from 0 to 3 months (CWT1) (n = 30), behavioural modification + exercise from 6 to 9 months (CWT2) (n = 30), and a control group (CON) (n = 30). Questionnaires and measurements were performed at baseline, 3,9,4 and 36 months. The intervention consisted of an intensified weight loss period (1-12 months) followed by a weight maintenance period (13-36 months). Intensified behavioural modification included 14 individual face to face meetings, eleven times with a personal therapist (qualified nurse) and three times with a nutritionist. Weight maintenance period included six individual meetings with personal therapist. Twelve weeks supervised exercise was offered three times a week, 40 minutes at a time. In the CWT1 group supervised exercise was offered at months 1-3 and in the CWT2 group at months 4-6.

Measurements Body weight (primary outcome) and waist circumference (secondary outcome)

Enrollment: 120 patients

Sex: All

Ages: 18 to 64 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Body mass Index > 30
• Age 18-64

Exclusion criteria

• Pregnancy
• Health reasons preventing exercise and exercise test
• Medication preventing exercise and exercise test
• Previously diagnosed diabetes

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 4 patient groups

Lifestyle modification

Experimental group

Description:

intensified Behavioural Modification (iBM) group receiving lifestyle counselling

Treatment:

Behavioral: Lifestyle modification

Lifestyle modification and exercise 1

Experimental group

Description:

Intensified Behavioural Modification and exercise from 0 to 3 months (CWT1) group: Lifestyle counselling 3 months Exercise intervention from 0 to 3 months

Treatment:

Behavioral: Lifestyle modification

Lifestyle modification and exercise 2

Experimental group

Description:

Intensified Behavioural Modification and exercise from 6 to 9 months (CWT2) group: Lifestyle counselling 3 months Exercise intervention from 6 to 9 months

Treatment:

Behavioral: Lifestyle modification

Control Group

No Intervention group

Description:

Control group, no intervention, only measurements and questionnaires