Effects of Physical Training on Adipose Tissue Metabolism and Insulin Sensitivity in the Menopausal Transition Phase

University of Copenhagen

Status: Completed

Conditions: Menopause; Insulin Resistance; Body Composition, Beneficial

Treatments: Behavioral: Spinning

Study type: Interventional

Funder types: Other

Identifiers

NCT02076932

CWS menopause, adipose tissue

Details and patient eligibility

About

The purpose of this study is to determine if physical exercise reduces the adverse changes in adipose tissue metabolism and insulin sensitivity that occurs in women during the menopausal transition.

Enrollment: 43 patients

Sex: Female

Ages: 45 to 57 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Premenopausal OR Postmenopausal (45-57 years)
• No chronical Diseases
• BMI > 18,5 and < 30
• Sedentary (no regular physical activity the last 2 years)
• Either regular bleeding (premenopausal) OR no menstruation for at least 2 years (postmenopausal)
• Plasma measurements:

Premenopausal: estradiol > 0.20nmol/l, Follicle Stimulating Hormone < 22 IU/l and progesterone > 2.5 nmol/l Postmenopausal: estradiol < 0.20nmol/l, Follicle Stimulating Hormone > 22 IU/l and progesterone from 0.3-2.5 nmol/l

Exclusion criteria

• Smoking
• Excessive alcohol intake
• Regular medication including hormone replacement treatment

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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43 participants in 2 patient groups

Premenopausal women

Active Comparator group

Description:

The premenopausal women will be attending Spinning classes.

Treatment:

Behavioral: Spinning

Postmenopausal Women

Experimental group

Description:

The postmenopausal women will be attending Spinning classes.

Treatment:

Behavioral: Spinning