Effects of Physical Training on Bone Turnover and Quality of Life in Osteopenic Postmenopausal Women.

University Of Perugia

Status: Completed

Conditions: Osteopenia; Bone Turnover Markers; Quality of Life

Treatments: Other: Physical exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03195517

OPCuriamo-1

Details and patient eligibility

About

The aim of our research was to define both in vivo and in vitro whether and to what extent an high-impact exercise program would affect bone cell turnover and improve the QoL in osteopenic postmenopausal women.

Full description

Subjects were selected among those attending the "Bone and Mineral Metabolism Disorders" Clinic of Perugia University, Italy, since May 2nd 2015 and January 31st 2016. A total of 33 post-menopausal women volunteered to participate in the study.

Enrollment: 33 patients

Sex: Female

Ages: 52 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• postmenopausal
• bone mineral density T-score less than -1 but more than -2.5 in the total hip or lumbar spine (L1-L4) by dual energy x-ray absorptiometry
• be able to attend an exercise program 2 times per week over the 3-month period
• stated availability throughout the entire study period

Exclusion criteria

• secondary causes of bone loss such as osteomalacia, glucocorticoid medication
• co-morbidities that would interfere with participation in exercise such as severe heart or pulmonary disease, inflammatory joint disease, severe osteoarthritis, psychiatric condition
• physical or orthopaedic disabilities that would place the subject at risk or limit their ability to perform exercise
• a past vertebral fracture
• history of chronic diseases, such as renal, hepatic, cardiac, and rheumatic diseases
• current or prior use of drugs that could interfere with bone mass (i.e. glucocorticoids, antiresorptive drugs and hormonal replacement therapy)

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Sequential Assignment

Masking: None (Open label)

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33 participants in 2 patient groups

Physical Exercise

Experimental group

Description:

The exercise program was performed at C.U.R.I.A.Mo. Institute of "Università degli Studi di Perugia". Twenty-four exercise sessions were provided, carried out twice a week for three months. Each session was supervised by two graduated trainers and two medical doctors with a maximum attendance of 5 patient/group. Each session lasted 45 minutes divided into 15 minutes of aerobic activity and 30 minutes of weight-bearing and resistance activities. This latter section was specifically projected for adults and older adults with increased risk of fractures and was intended to improve muscle strength and flexibility, balance and, as a result, to prevent the risk of falls.

Treatment:

Other: Physical exercise

No additional physical exercise

No Intervention group

Description:

Usual recommendations for prevention of fractures in adults and elderly.