Effects of Phytonutrients Upon Muscle Perfusion in Response to Feeding

Abbott

Status: Completed

Conditions: Biological Aging

Treatments: Other: Curcuminoid Cohort 2; Other: Flavonoid Cohort 3; Other: Catechin Cohort 1

Study type: Interventional

Funder types: Industry

Identifiers

NCT03213340

BL31

Details and patient eligibility

About

This is a random order cross over design trial to evaluate the efficacy of select nutritional ingredients on enhancing muscle perfusion in response to an acute meal stimulus.

Enrollment: 39 patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body mass index (BMI) 18-30 kg/m2
• Free from active metabolic disease
• Normotensive

Exclusion criteria

• Habitual gym use or formal exercise (more than once a week) or other routine strenuous physical activity
• Smokers
• Surgery within past 3 months
• Active cardiovascular disease
• Taking beta-adrenergic blocking agents
• Cerebrovascular disease:
• Active respiratory disease
• Active metabolic disease
• Active inflammatory bowel or renal disease
• Active Malignancy or until confirmed remission
• Clotting dysfunction
• History of DVT
• Significant musculoskeletal or neurological disorders
• Family history of early (<55y) death from cardiovascular disease
• Known sensitivity to Sonovue contrast agent
• Known allergy or intolerance to any of the study ingredients
• Current use of any of the study ingredients

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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39 participants in 3 patient groups

Catechin Cohort 1

Experimental group

Description:

2 treatment - Experimental Catechin Blend; Control 1 Placebo

Treatment:

Other: Catechin Cohort 1

Curcuminoid Cohort 2

Experimental group

Description:

2 treatment - Experimental Curcuminoid Blend; Control 1 Placebo

Treatment:

Other: Curcuminoid Cohort 2

Flavonoid Cohort 3

Experimental group

Description:

2 treatment - Experimental Flavonoid Blend; Control 2 Low-Flavonoid Blend

Treatment:

Other: Flavonoid Cohort 3