Effects of Pioglitazone in Hypertensive Patients

Tottori University Hospital

Status and phase: Completed; Phase 4

Conditions: Hypertension; Insulin Resistance

Treatments: Drug: Pioglitazone

Study type: Interventional

Funder types: Other

Identifiers

NCT01472497

PIO and HTN

Details and patient eligibility

About

Insulin resistance is often complicated with hypertension. AGE and inflammation play important roles in insulin resistance. Some studies reported that pioglitazone, insulin sensitizer, is effective for patients with insulin resistance, however, the mechanisms are still unclear. The aim of this study to evaluate the effect of pioglitazone compared with glimepiride on AGE, inflammatory cytokines and cardiac markers (BNP and echo) in hypertensive patients during oral glucose tolerance test.

Enrollment: 16 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hypertension with insulin resistance

Exclusion criteria

• Chronic systolic heart failure, ACS

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Double Blind

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16 participants in 1 patient group

glymepiride

Experimental group

Treatment:

Drug: Pioglitazone