Effects of Plant Based Lipids on Glucose Regulation and Cognitive Variables

Lund University

Status: Completed

Conditions: Obesity; Diabete Type 2

Treatments: Dietary Supplement: lipids

Study type: Interventional

Funder types: Other

Identifiers

NCT05276128

2018/658

Details and patient eligibility

About

The overall goal is to increase the knowledge that can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people. More specifically the primary purpose of this project is to evaluate effects in healthy humans on acute postprandial glucose regulation of plant based lipids. Due to the tight connection between cardiometabolic health and cognitive functions, a secondary issue is to investigate effects of test foods on cognitive test variables and mood parameters.

Enrollment: 17 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Apparently healthy subjects
• Between 20 and 40 years old
• Body mass index between 19-28 kg / m2),
• Consuming a non-vegetarian diet generally in line with the Nordic nutrition recommendations.

Exclusion criteria

• Fasting blood glucose concentration >6.1 mmol/L
• Known metabolic or gastrointestinal disorder (eg diabetes, high cholesterol, high blood pressure, IBS), or other disease that may affect the study results.
• Regular medication, except for long-term and stable medication for the lack or reduced production of thyroid hormone (eg Levaxin).
• Antibiotics or probiotics for at least four weeks before the start of the study,
• The use of tobacco products

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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17 participants in 5 patient groups

WWB Reference

Other group

Description:

White wheat bread (WWB) without lipid supplements. The effects of this high glycaemic product on postprandial glucose and insulin responses are well studied.

Treatment:

Dietary Supplement: lipids

WWB 5g active lipids

Experimental group

Description:

WWB supplemented with 5 g active lipids, and 10 g control lipids

Treatment:

Dietary Supplement: lipids

WWB 10g active lipids

Experimental group

Description:

WWB supplemented with 10g active lipids, and 5 g control lipids

Treatment:

Dietary Supplement: lipids

WWB 15g active lipids

Experimental group

Description:

WWB supplemented with 15g active lipids, and 0 g control lipids

Treatment:

Dietary Supplement: lipids

WWB 15 g control lipids

Active Comparator group

Description:

WWB supplemented with 15g control lipids

Treatment:

Dietary Supplement: lipids