Effects of Plant-based Meat Alternatives in Comparison to Chicken Meat on Postprandial Metabolism in Healthy Adults

University of Bonn

Status: Completed

Conditions: Postprandial Metabolic Events; Plasma Amino Acid Appearance and Disappearance

Treatments: Other: Chicken; Other: Wheat protein; Other: Pea protein; Other: Soy protein

Study type: Interventional

Funder types: Other

Identifiers

NCT06618729

AlProPlant-HS2

Details and patient eligibility

About

The aim of this study is to investigate the postprandial metabolic responses to plant-based meat alternatives made from different protein ingredients (pea, wheat or soy protein) in comparison to chicken in healthy adults. Therefore, young healthy subjects consume 4 test meals with 40 g of protein from pea protein, wheat protein, soy protein or chicken in a randomized order. In a postprandial period of 6 hours, parameters of protein, glucose and lipid metabolism (i.a. plasma amino acids), gastric emptying and hunger/satiety are analysed. It is assumed that the plasma amino acid profile after plant protein ingestion differs depending on protein source and in comparison to chicken protein.

Full description

In a randomized crossover-design, 20 healthy women and men consume 4 test meals containing either 40 g of protein from plant-based meat alternatives (pea, wheat and soy protein extrudate) or chicken together with 1 g paracetamol, which is used as a marker for gastric emptying.

During a postprandial period of 6 hours parameters of protein metabolism (e.g. amino acids in plasma and urine), glucose metabolism (e.g. plasma glucose, serum insulin), lipid metabolism (serum triglycerides, total cholesterol , LDL cholesterol, HDL cholesterol, free fatty acids), serum uric acids, hunger- and satiety-associated gastrointestinal hormones (serum ghrelin, plasma GLP-1), and gastric emptying rate (based on plasma paracetamol) are analysed. Furthermore, subjective hunger/satiety and acceptance of the meals are assed using visual analogue scales. Each intervention arm will be separated by a washout period of at least 7 days.

Enrollment: 20 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• non-smoking
• metabolically healthy
• normal weight (BMI: 18,5 - 24,9 kg/m2)
• written informed consent

Exclusion Criteria

• pregnancy, lactation
• hypo- or hypertension
• underweight or overweight/obesity
• food intolerances and allergies (especially soy, pea, wheat/gluten)
• malabsorption syndromes
• gastrointestinal diseases
• thyroid diseases
• diabetes mellitus type 1 and type 2
• impaired kidney or liver function
• anaemia
• blood coagulation disorders
• irregular menstrual cycle
• endometriosis, severe menstrual problems
• hormonal contraception
• regular use of medications (especially habitual use of paracetamol or medications that may interact with paracetamol)
• hypersensitivity to paracetamol
• body weight below 50 kg
• alcohol abuse
• glucose-6-phosphate dehydrogenase deficiency
• Gilbert's syndrome
• eating disorders (especially anorexia nervosa, bulimia nervosa)
• smoking
• participation in another study

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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20 participants in 4 patient groups

Pea protein

Experimental group

Description:

Participants randomized to receive a meal containing 40 g of protein from pea protein extrudate

Treatment:

Other: Pea protein

Wheat protein

Experimental group

Description:

Participants randomized to receive a meal containing 40 g of protein from wheat protein extrudate

Treatment:

Other: Wheat protein

Soy protein

Experimental group

Description:

Participants randomized to receive a meal containing 40 g of protein from soy protein extrudate

Treatment:

Other: Soy protein

Chicken

Active Comparator group

Description:

Participants randomized to receive a meal containing 40 g of protein from chicken meat

Treatment:

Other: Chicken