Effects of Plant-based Polar Lipids on Acute and Second Meal Glucose Tolerance and Appetite Sensations

Lund University

Status: Completed

Conditions: Diet Intervention; Healthy Subjects

Treatments: Other: Non-polar lipids; Other: No lipids; Dietary Supplement: Polar lipids low; Dietary Supplement: Polar lipids high

Study type: Interventional

Funder types: Other

Identifiers

NCT05844085

Prot.2018/8-Dnr.2018/658

Details and patient eligibility

About

The overall goal of the project is to increase knowledge which can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people. More specifically the primary purpose is to evaluate effects on cardiometabolic test markers of bioactive compounds in healthy humans. Previously the investigators reported beneficial effects of oat polar lipids on cardiometabolic risk markers. In this study the effects previously observed will be compared with cardiometabolic effects of another plant based lipid.

Enrollment: 20 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Apparently healthy men and women
• non-smokers
• between 20-40 years of age
• BMI between 18,5-30 kg/m2
• No known metabolic disorders or food allergies.
• The test subjects should follow a normal diet in accordance with the Nordic Nutrition Recommendations.

Exclusion criteria

• Fasting blood glucose ≥6.1 mmol/L
• Use of antibiotics or probiotics in the last three months or during the study period.
• Smoking
• Blood donation during the last two months and during the study.
• Food allergies or food intolerances
• CVD
• Metabolic diseases
• Inflammatory bowel diseases.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

---

20 participants in 4 patient groups, including a placebo group

Non-polar lipids

Sham Comparator group

Description:

A food product containing 15 g plant-based non-polar lipids. The fat is consumed blended with a carbohydrate source containing 50 g available carbohydrates.

Treatment:

Other: Non-polar lipids

No Lipids

Placebo Comparator group

Description:

Reference product. A carbohydrate source containing 50 g available carbohydrates.

Treatment:

Other: No lipids

Polar Lipids low

Experimental group

Description:

A food product containing 15 g plant-based lipids, of which 50% is polar lipids and 50% is non-polar lipids.The fat is consumed blended with a carbohydrate source containing 50 g available carbohydrates.

Treatment:

Dietary Supplement: Polar lipids low

Polar Lipids high

Experimental group

Description:

A food product containing 15 g plant-based lipids, of which 100 % is polar lipids. The fat is consumed blended with a carbohydrate source containing 50 g available carbohydrates.

Treatment:

Dietary Supplement: Polar lipids high