Effects of Plant Polar Lipids on Glucose Tolerance

Anne Nilsson

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Non-polar lipids; Dietary Supplement: Polar lipid 1; Other: No lipids; Dietary Supplement: Polar lipid 2

Study type: Interventional

Funder types: Other

Identifiers

NCT06148974

Prot.2018/8-23

Details and patient eligibility

About

In this randomized controlled trial, two different plant polar lipids are investigated with respect to their potential to affect acute and second meal glucose tolerance and appetite sensations. The effects are compared with a common non-polar commercial oil. The lipids are consumed spread on a white wheat bread. A white wheat bread without added lipids is included as a control product. The test products are consumed at breakfast, and test variables are investigated in the postprandial period after the test breakfast and also after a second meal standard lunch.

Enrollment: 17 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Apparently healthy men and women
• non-smokers
• between 20-40 years of age
• BMI between 18,5-30 kg/m2
• No known metabolic disorders or food allergies.
• The test subjects should follow a normal diet in accordance with the Nordic Nutrition Recommendations.

Exclusion criteria

• Fasting blood glucose ≥6.1 mmol/L
• Use of antibiotics or probiotics in the last three months or during the study period.
• Smoking
• Blood donation during the last two months and during the study.
• Food allergies or food intolerances
• Cardiovascular diseases
• Metabolic diseases
• Inflammatory bowel diseases.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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17 participants in 4 patient groups, including a placebo group

Polar lipid 1

Experimental group

Description:

15 g Plant polar lip 1 consumed with a white wheat bread including 50 g available carbohydrates

Treatment:

Dietary Supplement: Polar lipid 1

Polar lipid 2

Experimental group

Description:

15 g Plant polar lipids 2 consumed with a white wheat bread including 50 g available carbohydrates

Treatment:

Dietary Supplement: Polar lipid 2

non-polar lipids

Active Comparator group

Description:

15 g commonly consumed non-polar lipids consumed with a white wheat bread including 50 g available carbohydrates

Treatment:

Dietary Supplement: Non-polar lipids

no lipids

Placebo Comparator group

Description:

A white wheat bread including 50 g available carbohydrates

Treatment:

Other: No lipids