Effects of Platelet-Rich Fibrin and Kinesio Taping on Postoperative Recovery in Oral Surgery (PRFKTOralSur)

Mustafa Kemal University

Status: Completed

Conditions: Postoperative Pain; Impacted Third Molar Tooth; Postoperative Edema

Treatments: Other: Standard Postoperative Care; Biological: Platelet-Rich Fibrin (PRF); Device: Kinesio Taping

Study type: Interventional

Funder types: Other

Identifiers

NCT06900894

PRF_KT2025

Ethics Committee No. (Registry Identifier)

Details and patient eligibility

About

This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in reducing postoperative pain, edema, and improving recovery following impacted third molar surgery. A prospective, randomized clinical trial was conducted with 44 patients aged 18-35 years. Patients were assigned to three groups: (1) PRF applied locally to the extraction socket, (2) Kinesio Taping applied postoperatively and removed on the third day, and (3) a control group receiving standard postoperative care. Postoperative outcomes were assessed on days 3 and 7, including pain levels, edema, and quality of life. This study aims to evaluate PRF and Kinesio Taping as non-pharmacological adjuncts in oral and maxillofacial surgery.

Full description

This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in postoperative management following impacted mandibular third molar surgery. Postoperative complications, such as pain and edema, are commonly observed and may impact patient comfort and recovery. This study aims to evaluate the feasibility of two non-pharmacological approaches-PRF and Kinesio Taping (Elastic Bandaging)-in postoperative care.

A total of 44 patients aged 18-35 years participated in this prospective, randomized clinical trial. Patients were assigned to one of three groups:

PRF Group: Platelet-rich fibrin (PRF) was applied locally into the extraction socket.

Kinesio Taping Group: An elastic bandage was applied postoperatively to the surgical area and removed on the third day.

Control Group: Standard postoperative care was provided with no additional intervention.

Postoperative evaluations were conducted on the 3rd and 7th days. The measured parameters included:

Edema: Measured using anthropometric techniques.

Pain: Assessed with the Numerical Rating Scale (NRS).

Quality of Life: Evaluated using the Oral Health Impact Profile-14 (OHIP-14).

This study aims to assess the feasibility of PRF and Kinesio Taping in postoperative management.

Enrollment: 44 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ages 18-35 years
• Systemically healthy individuals
• Non-smokers
• No psychological disorders
• Preoperative pain level between 0-3 on the Numerical Rating Scale (NRS)
• No preoperative edema in the surgical area
• Impacted mandibular third molars classified as Class 1 or 2, Level B, and mesioangular according to the Pell-Gregory classification
• Signed an informed consent form

Exclusion criteria

• Under 18 or over 35 years old
• Presence of chronic or systemic diseases
• Pregnant or breastfeeding patients
• Surgical duration exceeding 45 minutes
• Smokers
• Patients requiring prophylactic antibiotics due to systemic health conditions
• Patients who did not meet the study criteria or did not sign the informed consent form

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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44 participants in 3 patient groups

PRF Group

Experimental group

Description:

Participants in this group received Platelet-Rich Fibrin (PRF) applied to the extraction socket following impacted third molar surgery. PRF was prepared using a centrifugation protocol and placed into the surgical site.

Treatment:

Biological: Platelet-Rich Fibrin (PRF)

Kinesio Taping Group

Experimental group

Description:

Participants in this group received Kinesio Taping applied postoperatively. The elastic therapeutic tape was applied to the masseter and submandibular region following a standardized taping protocol.

Treatment:

Device: Kinesio Taping

Control Group

Other group

Description:

Participants in this group received standard postoperative care, including routine pain management and wound care, without additional interventions.

Treatment:

Other: Standard Postoperative Care