Effects of Platelet-Rich Fibrin in Patients With Anterior Cruciate Ligament Reconstruction

Hacettepe University

Status and phase: Completed; Phase 4

Conditions: Effects of Platelet-Rich Fibrin on Knee Stability and Knee Function

Treatments: Other: Standard ACL reconstruction surgery; Biological: Platelet-Rich Fibrin during Standard ACL reconstruction surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT05904158

E-18-2060

Details and patient eligibility

About

The study was conducted to investigate the effects of platelet-rich fibrin on knee stability, knee muscle strength and knee function in patients with ACL reconstruction. Thirty patients with ACL reconstruction were included to the study and randomly divided into two groups. Patients were assessed preoperative and at the postoperative 1-year.

Full description

The study was conducted yo investigate the effects of platelet-rich fibrin (PRF) on the knee stability and function in patients with anterior cruciate ligament (ACL) reconstruction. Thirty patients with ACL reconstruction were included to the study and randomly divided into two groups (PRF group and control group). Hamstring tendon autograft was used in all patients for the reconstruction of the teared ACL. A standardized postoperative rehabilitation program was applied to all patients. Patients' knee stability, knee muscle strength and knee function were assessed preoperatively and one-year postoperatively. Knee stability was assessed using KT-2000 Knee Arthrometer. Quadriceps femoris and hamstring muscle strength measurements were conducted with an isokinetic dynamometer at 60˚/sec and 180˚/sec angular velocities. One Leg Hop (OLH) and Y-Balance tests, and International Knee Documentation Committee (IKDC) were used to evaluate the knee function.

Enrollment: 30 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Being isolated ACL reconstruction,
• Being between the ages of 18-45 years,
• Performing sports recreationally or professionally

Exclusion criteria

• Having previous knee surgery,
• Having systematic disease,
• Having multiple ligament injury on the knee or additional cartilage injuries

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

PRF Group

Experimental group

Description:

Patients in this group, received PRF application during the standard ACL reconstruction surgery

Treatment:

Biological: Platelet-Rich Fibrin during Standard ACL reconstruction surgery

Control Group

Active Comparator group

Description:

Patients in this group received a standard ACL reconstruction surgery without any other intervention.

Treatment:

Other: Standard ACL reconstruction surgery