Effects of Platelet-Rich Plasma and Ozone Therapy in Knee Osteoarthritis

Sisli Hamidiye Etfal Training and Research Hospital

Status: Completed

Conditions: Knee Osteoarthritis

Treatments: Other: Ozone therapy; Other: PRP injection

Study type: Observational

Funder types: Other

Identifiers

NCT06631456

09/07/2024-4460

Details and patient eligibility

About

Knee osteoarthritis can frequently occur with advancing age. In cases of pain that persists despite hot/cold applications, drug therapy and exercise, intra-articular injections are considered. In advanced-stage gonarthrosis, steroid injections may respond. However, in mild and moderate knee arthritis, regenerative methods come to the forefront because the joint cartilage is still partially/completely intact. PRP and ozone therapy are frequently applied intra-articular treatments. This study will compare the effects of both injection methods on clinical outcomes.

Full description

Knee osteoarthritis is a common arthrosis that can be encountered frequently with increasing life expectancy. In mild-moderate stages, hot/cold applications, drug treatments and exercise applications are usually applied, while in those who do not respond, physical therapy or intra-articular injection treatments are applied. This retrospective study aims to examine the effects of intra-articular Platelet Rich Plasma (PRP) and ozone therapy on pain, functionality and quality of life in patients with Stage 2-3 gonarthrosis according to the Kelgren-Lawrence (KL) Classification.

Enrollment: 54 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 30-70 years old, Stage 2-3 gonarthrosis according to KL
• Voluntariness to participate in the study

Exclusion criteria

• Cognitive dysfunction
• General medical condition is not suitable for injections and evaluations
• History of knee injections in the last 3 months
• History of previous knee surgery
• Bleeding disorders or those taking medications that may cause bleeding disorders after injections

Trial design

54 participants in 2 patient groups

PRP group

Description:

Patients who received intra-articular PRP due to gonarthrosis

Treatment:

Other: PRP injection

Ozone group

Description:

Patients who received intra-articular ozone therapy due to gonarthrosis

Treatment:

Other: Ozone therapy