Effects of Platelet Rich Plasma on Endometrium

Acibadem University

Status

Completed

Conditions

Asherman Syndrome

Treatments

Biological: PRP injection in the endometrium

Study type

Interventional

Funder types

Other

Identifiers

NCT04424160

KA20/23

Details and patient eligibility

About

Intrauterine platelet rich plasma will be injected in the endometrial region via the vaginal route after the cessation of menstrual period. The endometrial thickness will be assessed under ultrasound and hormone replacement will be started. As the endometrial thickness reaches adequate thickness during ultrasound follow-up, embryo transfer will be performed.

Full description

Intrauterine platelet rich plasma will be injected in the endometrial region via the vaginal route after the cessation of menstrual period. In the second menstrual period following the PRP injection, the endometrial thickness will be assessed under ultrasound and hormone replacement will be started. As the endometrial thickness reaches adequate thickness during ultrasound follow-up, embryo transfer will be performed. Pregnancy test results will be recorded and followed.

Enrollment

150 patients

Sex

Female

Ages

20 to 45 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Women in whom cycle was cancelled due to an endometrial thickness <7 mm when progesterone start was planned in patients undergoing frozen embryo transfer with hormone replacement therapy
Women with a history of Asherman syndrome, but no obvious intrauterine adhesion in the last hysteroscopic procedure;
Women who have at least 2 frozen good-quality embryos.

Exclusion criteria

Women with any other known cause of implantation failure, such as poor embryo quality, or congenital uterine anomalies, endometrial polyp or fibroid,
Previous diagnosis of any malignancy,
Anticoagulant use for which plasma infusion is contraindicated,