Effects of Polyvinylpyrrolidone Iodine on Postoperative Trismus and Swelling During Impacted Third Molar Surgery

Cansu Gül Koca

Status and phase: Completed; Phase 4

Conditions: Impacted Third Molar Tooth

Treatments: Procedure: Control; Procedure: 0.5% concentration of PVP-I; Procedure: 1 % concentration of PVP-I; Procedure: 3 % concentration of PVP-I

Study type: Interventional

Funder types: Other

Identifiers

NCT03894722

CHR: 2016-8/11

Details and patient eligibility

About

The aim of the present study was to evaluate the effects of different concentrations of povidone iodine (PVP-I) on postoperative swelling and trismus when used as a coolant and irrigation solution during the surgical removal of impacted mandibular third molars.

Enrollment: 80 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Totally impacted mandibular third molars of class C, 1, 2, and 3 according to the Pell-Gregory classification;
• Has no systemic disease

Exclusion criteria

• The use of medications that could interfere with the healing process;
• Smoking;
• Pregnancy or lactation;
• Presence of any condition, such as inflammation, periodontitis, gingivitis and dental abscess in the area of the impacted teeth;
• Undergoing antibiotic or anti-inflammatory drugs therapies in the 7 days before surgery;
• History of hypersensitivity to iodine;
• Has any thyroid diseases.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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80 participants in 4 patient groups, including a placebo group

Group I (control; saline only)

Placebo Comparator group

Description:

Control Group: Intraoperative irrigation with saline solution only.

Treatment:

Procedure: Control

Group II (0.5% concentration of PVP-I )

Experimental group

Description:

Experimental Group: Intraoperative irrigation with 0.5% concentration of PVP-I solution.

Treatment:

Procedure: 0.5% concentration of PVP-I

Group III (1% concentration of PVP-I)

Experimental group

Description:

Experimental Group: Intraoperative irrigation with 1% concentration of PVP-I solution.

Treatment:

Procedure: 1 % concentration of PVP-I

Group IV (3% concentration of PVP-I)

Experimental group

Description:

Experimental Group: Intraoperative irrigation with 3% concentration of PVP-I solution.

Treatment:

Procedure: 3 % concentration of PVP-I