Effects of Pomegranate Juice on Oxidative Stress in Patients With type2 Diabetes

National Nutrition and Food Technology Institute

Status and phase: Completed; Phase 4

Conditions: Diabetes Type 2

Treatments: Behavioral: lifestyle modification; Dietary Supplement: pomegranate juice

Study type: Interventional

Funder types: Other

Identifiers

NCT02559843

611

Details and patient eligibility

About

Introduction: Diabetes mellitus a chronic diseases, is the most common and important metabolic disease in human. Increased free radicals production due to hyperglycemia produces oxidative stress which worsens the disease and its complications. Pomegranate juice has antioxidant and antiatherosclerotic properties. The present study was planned to evaluate the effects of pomegranate juice consumption on glycemic control, lipid profile,blood pressure and oxidative stress in patients with type 2 diabetes

Enrollment: 60 patients

Sex: All

Ages: 40 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age of 40-65 years
• Body Mass Index 18.5-30
• Fasting blood glucose ≥ 126 mg/dl

Exclusion criteria

• Smoking
• insulin for blood glucose control
• taking estrogen or progesterone (if female)
• Taking antioxidant supplements
• suffering from any other chronic diseases
• Participants are also excluded if they missed more than 10% of their pomegranate juice packs

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

60 participants in 2 patient groups

pomegranate juice

Experimental group

Description:

200 ml pomegranate juice + lifestyle modification

Treatment:

Dietary Supplement: pomegranate juice

control

Active Comparator group

Description:

lifestyle modification including dietary recommendations

Treatment:

Behavioral: lifestyle modification