Effects of Postconditioning On Myocardial Reperfusion (POST)

Samsung Medical Center

Status

Completed

Conditions

Myocardial Reperfusion

Myocardial Infarction

Treatments

Procedure: Post-conditioning

Study type

Interventional

Funder types

Other

Identifiers

NCT00942500

2009-02-007

Details and patient eligibility

About

The purpose of this study is to investigate the effects of postconditioning on myocardial reperfusion in patients with ST-segment elevation myocardial infarction.

Enrollment

700 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria General Inclusion Criteria

Subject must be at least 18 years of age.
Subject is able to verbally confirm understandings of risks, benefits and treatment alternatives of receiving postconditioning and he/she or his/her legally authorized representative provides written informed consent prior to any study related procedure
Diagnosis of STEMI
1. presence of chest pain for more than 30 minutes but less than 12 hours after symptom onset
2. ST-segment elevation more than 1 mm in at least 2 contiguous leads

Angiographic Inclusion Criteria

Target lesion(s) must be located in a native coronary artery
Target lesion(s) must be amenable for percutaneous coronary intervention
TIMI flow grade of infarct related arteries <2

General Exclusion Criteria

Patients with hemodynamic instability or those with cardiogenic shock
Target lesion is located in left main stem
Rescue PCI after thrombolysis or facilitated PCI
Non-cardiac co-morbid conditions are present with life expectancy <1 year or that may result in protocol non-compliance (per site investigator's medical judgment)
Female of childbearing potential, unless a recent pregnancy test is negative, who possibly plan to become pregnant any time after enrollment into this study