Effects of Postoperative Analgesic Modalities on Plasma Creatine Phosphokinase(CPK) Levels After Knee Artroplasty

Samsun University

Status: Completed

Conditions: Myotoxicity

Treatments: Other: suprainguinal fascia iliaca block

Study type: Observational

Funder types: Other

Identifiers

NCT05505890

SamsunU_SFIPB

Details and patient eligibility

About

Regional anesthesia and analgesia technics are widely and securely used during orthopedic surgery. Interfascial plane blocks are the latest used ones for analgesia. There are studies in literature indicating that bupivacaine cause myotoxicity. We aimed to examine plasma CPK(creatine phosphokinase) levels to see whether myotoxicity occurs or not after suprainguinal fascial plane block is applied to patients undergoing knee artroplasty surgery.

Full description

During 2 months period all elligible patients undergoing knee artoplasty surgery will be included in the study. Different postoperative analgesic modalities will be used according to the anesthesists experience. During routine blood sample tests plasma CPK levels will be tested 3 times of all patients.(preoperative, postoperative 6th hour, postoperative 24th hour) this data will be recorded for 2 months. After this period of time data will be analysed and patients will be grouped according to the analgesic modalities used.

Enrollment: 82 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA 1-3
• knee artoplasty patients
• under spinal anesthesia

Exclusion criteria

• local anesthetic allergies
• myopathies
• coagulopathies
• Obstructive sleep apne syndrome
• hearth diseases
• liver diseases
• kidney diseases
• thyroid-parathyriod dieseas
• hiperlipidemias using Statins(HMG-CoA reductase inhibitors)
• pregnancy

Trial design

82 participants in 2 patient groups

SFIPB

Description:

suprainguinal fascia iliaca plane block with 50ml of %0.25 bupivacaine will be used for postoperative analgesia .

Treatment:

Other: suprainguinal fascia iliaca block

control

Description:

Fascia iliac block will not be applied to this group. Postoperative analgesia will be provided with other analgesia modalities.