Effects of Postoperative Pain Management on Immune Function After Laparoscopic Resection of Colorectal Cancer

Yonsei University

Status: Completed

Conditions: Colorectal Surgery

Treatments: Drug: local anesthetic wound infiltration-based anlagesia; Drug: fentanyl-based analgesia

Study type: Interventional

Funder types: Other

Identifiers

NCT02012244

4-2013-0044

Details and patient eligibility

About

The purpose of this study is to compare postoperative immune function (e.g. NK cell activity) of fentanyl-based analgesic regimen versus local anesthetic wound infiltration-based anlagesic regimen after laparoscopic colorectal surgery

Enrollment: 60 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA class I-III
• 20-80 years old
• elective laparoscopic colorectal surgery for cancer

Exclusion criteria

• drug allergy
• significant renal or hepatic impairment
• sign of infection

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

fentanyl-based analgesia

Experimental group

Description:

fentanyl intravenous patient-controlled analgesia + additional pethidine

Treatment:

Drug: fentanyl-based analgesia

local anesthetic wound infiltration-based anlagesia

Experimental group

Description:

continuous wound inflitration with ropivacaine + tramadol intravenous patient-controlled analgesia + additional ketorolac or propacetamol

Treatment:

Drug: local anesthetic wound infiltration-based anlagesia