Effects of Postoperative Residual Paralysis on Hospital Costs

Mass General Brigham

Status: Unknown

Conditions: Residual Paralysis, Post-Anesthesia

Treatments: Procedure: Quantitative measurement of neuromuscular transmission

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01718860

IISP#39443 (Other Grant/Funding Number)

2016P002695

Details and patient eligibility

About

This is a secondary analysis of a previously performed prospective, observer-blinded, observational study at Massachusetts General Hospital. The primary aim of this study is to evaluate the effects of residual paralysis at admission to the post-anesthesia care unit (PACU) on total costs of hospital care.

Secondary analyses will be conducted to evaluate the effects of postoperative residual paralysis on potential cost-influencing factors, i.e. incidence of minor and major postoperative respiratory complications, hospital length of stay (LOS), unplanned intensive care unit (ICU) admission rate, as well as length of stay in the PACU.

Enrollment: 3,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Each subject has been given non-depolarizing neuromuscular blocking agents as part of general anesthesia.
• Each subject must be at least 18 years of age
• Train-of-four monitoring in the post-anesthesia care unit

Exclusion criteria

• The subject is scheduled to be transferred to an intensive care unit after surgery.
• Children and pregnant women

Trial design

3,000 participants in 2 patient groups

Postoperative Residual Paralysis

Description:

Patients with train-of-four ratio less than 0.9 measured in the postanesthesia care unit

Treatment:

Procedure: Quantitative measurement of neuromuscular transmission

No Postoperative Residual Paralysis

Description:

Patients with train-of-four ratio greater than 0.9 measured in the postanesthesia care unit

Treatment:

Procedure: Quantitative measurement of neuromuscular transmission