Effects of Prebiotics on GLP-1 in Type 2 Diabetes

University of Oslo (UIO)

Status: Completed

Conditions: Diabetes Type 2

Treatments: Dietary Supplement: Maltodextrin; Dietary Supplement: Prebiotic fibers: oligofructose and inulin

Study type: Interventional

Funder types: Other

Identifiers

NCT02569684

1180 REK

Details and patient eligibility

About

The aim of the study is to compare the effects of prebiotics versus placebo on blood concentrations of glucagon-like peptide-1 in subjects with diabetes type 2.

Full description

We looked at 6 weeks supplementation with a prebiotic fibre mix of inulin and FOS. Cross over design compared to maltodextrin as placebo. Additional outcome measures: blood glucose, insulin, GLP-2, ghrelin, PYY and leptin after a standardized mixed meal test. Also measured changes in microbiota composition and SCFA in feces before and after intervention/placebo periods, and subjective measures of appetite.

Enrollment: 37 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diabetes type 2
• BMI 18,5 - 40
• Not medicated with insulin, GLP-1 analogues or DPP4 inhibitors
• Moderate intake of alcohol
• Not excessive exercise
• Less than 3 kg weight change the last two months
• Intake of less than 30 g dietary fiber per day

Exclusion criteria

• IBD
• IBS
• Coeliac disease
• Have used antibiotics within the last two months
• Have used supplements with prebiotics or probiotics the last two months
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

---

37 participants in 2 patient groups, including a placebo group

Arm A

Active Comparator group

Description:

Prebiotic fibers: Oligofructose and inulin

Treatment:

Dietary Supplement: Prebiotic fibers: oligofructose and inulin

Arm B

Placebo Comparator group

Description:

Maltodextrin

Treatment:

Dietary Supplement: Maltodextrin