Effects of Preconditioning With Sevoflurane During Organ Procurement From Brain Dead Donors: Impact on Early Function of Liver Allografts

University of Liege

Status and phase: Unknown; Phase 4

Conditions: Post-transplantation Liver Allograft Function

Treatments: Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02341833

2014-26-06

Details and patient eligibility

About

The aim of the investigators study is to investigate the effects of anaesthetic preconditioning with sevoflurane during organs harvesting in brain dead donors. More particularly, the investigators will investigate whether sevoflurane preconditioning protects against ischaemia-reperfusion the livers and kidneys allografts after a prolonged period of cold ischaemia and whether this protection translates in a better clinical functional recovery of these allografts.

Enrollment: 240 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• all consecutive brain dead donors in the Belgian university hospitals of Leuven, Brussels, Louvain and Liège eligible for organs harvesting followed by organs transplantation in the Eurotransplant area. There is no age limitation for eligibility

Exclusion criteria

• haemodynamic instability that precludes safe administration of 2% sevoflurane.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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240 participants in 2 patient groups

Sevoflurane

Active Comparator group

Description:

1 MAC of sevoflurane for 15 minutes before organs procurement.

Treatment:

Drug: Sevoflurane

No intervention

No Intervention group

Description:

No volatile anesthetics during organs procurement