Effects of Prednisolone and Infliximab on the Regulation of Urea Synthesis in Active Inflammatory Bowel Disease

University of Aarhus

Status: Completed

Conditions: Inflammatory Bowel Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT00955123

FHNC-KLT

Details and patient eligibility

About

Loss of total mass of muscles (catabolism) is a serious clinical problem in patients with active inflammatory bowel disease (IBD). The investigators have earlier shown that the liver plays an important role in this stress-catabolism by increasing the production of urea during the inflammatory process.

The purpose of this study is to examine the effect of the anti-inflammatory drugs prednisolone and infliximab on the regulation of the urea synthesis in patients with active ulcerative colitis and Crohn's disease.

Enrollment: 40 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Moderate to severe active inflammatory bowel disease

Exclusion criteria

• Viral or bacterial infections
• Other chronical inflammatory diseases
• Cancer
• Other catabolic diseases
• Treatment with prednisolone or infliximab within the last 8 weeks

Trial design

40 participants in 1 patient group

Active inflammatory bowel disease

Description:

Patients with moderate to severe active inflammatory bowel disease (ulcerative colitis and Crohn's disease)