Effects of Prednisolone and Pentoxifylline on the Regulation of Urea Synthesis in Alcoholic Hepatitis

University of Aarhus

Status: Completed

Conditions: Alcoholic Hepatitis

Study type: Observational

Funder types: Other

Identifiers

NCT01245257

FHNC-Alk-Hep

Details and patient eligibility

About

Loss of total mass of muscles (catabolism) is a serious clinical problem in patients with alcoholic hepatitis. The liver might play an important role in this stress-catabolism by increasing the production of urea during the inflammatory process.

The purpose of this study is to examine the regulation of urea synthesis in patients with alcoholic hepatitis and to study the effect of the anti-inflammatory drugs prednisolone and pentoxifylline on this regulation.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Alcoholic hepatitis (alcohol intake (> 40g/day in 6 months), bilirubin > 80 μmol/l)

Exclusion criteria

• Severe bacterial infections
• Other chronical inflammatory diseases
• Cancer
• Other catabolic diseases
• Treatment with prednisolone or pentoxifylline within the last 8 weeks

Trial design

50 participants in 1 patient group

Alcoholic Hepatitis

Description:

Patients with alcoholic hepatitis