Effects of Preoperative Dexamethasone Study on QOL After Vaginal Reconstructive Surgery for POP

TriHealth

Status and phase

Completed

Phase 3

Conditions

PONV

Pelvic Organ Prolapse

Treatments

Drug: Placebo

Drug: Dexamethasone

Study type

Interventional

Funder types

Other

Identifiers

NCT02073734

12136-12-081

Details and patient eligibility

About

The investigators hypothesize that preoperative administration of 8 mg IV dexamethasone will benefit patients' perceived quality of recovery after surgery.

Full description

This is a randomized controlled trial involving single administration of 8 mg Dexamethasone per IV preoperatively among women undergoing vaginal reconstructive surgery for pelvic organ prolapse.

Enrollment

63 patients

Sex

Female

Ages

18 to 81 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Women aged 18-81 years old who are scheduled to undergo a major vaginal reconstructive surgery, including hysterectomy with or without hysterectomy

Exclusion criteria

Daily use of steroids or antiemetic agents such as Zofran, Reglan, Compazine and Phenargan within one month of surgery
Regional anesthesia for surgical procedure
Chronic pain requiring opioid treatment daily
History of allergy to the study medication
Severe renal and liver disease
Pregnancy
Non English speaking
Psychiatric disorder that will preclude completion of questionnaires
Minor surgery that does not involve overnight admission
Surgery that does not involve hysterectomy or vaginal intraperitoneal apical suspension
Hypersensitivity reaction to steroids
Evidence of systemic fungal infection
Evidence of any systemic infection
Uncontrolled diabetes