Effects of Preoperative Oral Carbohydrates Loading in Patients at High Risk of Postoperative Nausea and Vomiting Undergoing Spinal Surgery

Yonsei University

Status and phase: Unknown; Phase 4

Conditions: Spinal Disease

Treatments: Other: oral carbohydrate beverage; Other: control group

Study type: Interventional

Funder types: Other

Identifiers

NCT02809950

4-2015-0984

Details and patient eligibility

About

Many patients receiving opioid based analgesia after spinal surgery experience postoperative nausea and vomiting (PONV) despite prophylaxis and treatment with antiemetic agents. Dehydration caused by fasting prior to surgery is associated with the development of PONV. The aim of this study is to investigate the effect of oral carbohydrates loading prior to surgery in patients at high risk of PONV undergoing spinal surgery.

Enrollment: 288 estimated patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• female patient between 20 and 65 of age with ASA physical status Ⅰ-Ⅱ
• patient scheduled for elective spine surgery
• no smoking history

Exclusion criteria

• hepatorenal disease
• BMI > 35 kg/m2
• gastrointestinal disease
• vomiting within 24h
• administration of antiemetics or opioids within 24 h prior to surgery
• pregnant
• problem with communication

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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288 participants in 2 patient groups, including a placebo group

oral carbohydrate beverage group

Experimental group

Treatment:

Other: oral carbohydrate beverage

control group

Placebo Comparator group

Treatment:

Other: control group