Effects of Probiotic Capsules in Promoting Fat Excretion by Human Trial

Chung Shan Medical University

Status: Enrolling

Conditions: Obesity

Treatments: Dietary Supplement: probiotics; Dietary Supplement: placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT05607524

CS2-22068

Details and patient eligibility

About

The purpose of this study was to evaluate the efficacy of 2 capsules (500 mg per capsule, 1000 mg per day) of Grape King Probiotic Capsules per day in promoting fat excretion in obese patients by clinical human food test.

Full description

This experiment is carried out in a controlled manner. Before the subjects enter the research experiment, they need to follow their original lifestyle. The habits of maintaining a constant body weight for more than 2 weeks before the test, such as calorie balance in the diet and the amount of activity. Then enter the test to carry out the evaluation test of probiotics to the end. 60 subjects were randomized, 20 to placebo and 40 to probiotics. The subjects took two capsules of Grape King probiotics daily, a total of 1000 mg. Continue to take it for 4 weeks, and perform blood routine tests. Body composition detection, waist and hip circumference measurement, related index analysis and 24-hour dietary questionnaires, gut health questionnaires and stool samples were collected and analyzed for 4 weeks before and after treatment.

Enrollment: 60 estimated patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male or female participants
• aged 20-40 years old
• body mass index in 25-27 kg/m2
• body fat > 25% for men and > 30% for women

Exclusion criteria

• cancer, chronic heart disease, use drugs which pharmacological effects may affect immunity
• having systemic infections
• using probiotics.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups, including a placebo group

Probiotics

Experimental group

Description:

Probiotic capsules, 500 mg each, two daily for a total of 1000 mg for 4 weeks

Treatment:

Dietary Supplement: probiotics

Placebo

Placebo Comparator group

Description:

The placebo capsules had the same composition as the experimental capsules, except that they did not contain probiotics, and should be used for 4 weeks.

Treatment:

Dietary Supplement: placebo