Effects of Probiotics on Streptococcus Mutans ve Lactobacillus Spp

Didem Sakaryali Uyar

Status: Completed

Conditions: Streptococcus Mutans; Tooth Decay; Probiotics

Treatments: Dietary Supplement: Probiotic use

Study type: Interventional

Funder types: Other

Identifiers

NCT05859646

D-KA 19/41

Details and patient eligibility

About

To evaluate the change of S. mutans and Lactobacillus spp. counts after all dental treatments were completed under general anesthesia and compare the groups in case of using probiotics and not using probiotics with the time for 6-months follow-up period.

Full description

Fifthy-eight pediatric patients without any systemical diseases whose dental treatments were completed under general anesthesia were included in the study. The study was carried out as two-groups; Group A: Patients who started using probiotics after general anesthesia and Group B: Patients who did not use probiotics after general anesthesia. The counts of S. mutans and Lactobacillus spp. were determined by quantitative polymerase chain reaction (qPCR) by analysis of saliva samples taken from all patients on the day before the general anesthesia (T0), at 1-month (T1), 3-month (T2) and 6-month (T3) follow-up periods. The statistical significance level was accepted as p<0.05.

Enrollment: 58 patients

Sex: All

Ages: 2 to 12 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Every included child had at least 8 tooth with caries.

Exclusion criteria

• Patients who would not be able to give saliva samples due to high anxiety or lack of saliva were not included in this study.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

58 participants in 2 patient groups

Probiotics

Experimental group

Description:

Group A-Probiotics group: Patients who started using probiotic drops after general anesthesia procedure

Treatment:

Dietary Supplement: Probiotic use

Control

No Intervention group

Description:

Group B-Control group: Patients who did not use any probiotics after general anesthesia procedure