Effects of Propofol and Isoflurane on Pulmonary Vascular Resistance

University Hospitals Bristol and Weston NHS Foundation Trust

Status and phase: Completed; Phase 4

Conditions: Hypertension, Pulmonary

Treatments: Drug: propofol and isoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT01212523

2009-010614-30 (Registry Identifier)

CH/2007/2476

Details and patient eligibility

About

The investigators hypothesize that there is no difference between the effects of isoflurane and propofol anaesthesia on pulmonary vascular resistance (PVR).

Enrollment: 10 patients

Sex: All

Ages: 3 months to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All children between 3 months and 16 years of age with pulmonary arterial hypertension undergoing a PVR study.

Exclusion criteria

• Children with a known adverse reaction to one of the study drugs eg malignant hyperpyrexia or a disorder of fatty acid oxidation.

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind