Effects of Propofol and Ketofol on Core Body Temperature in MRI

Istanbul University

Status: Completed

Conditions: Children

Treatments: Drug: propofol; Drug: Ketamine propofol mixture

Study type: Interventional

Funder types: Other

Identifiers

NCT02931786

118099

Details and patient eligibility

About

Investigators researched the effect of two different types of drugs on core body temperature during magnetic resonance imaging. The hypothesis is in ketamine group, thermo disregulation is not as distinct as in propofol group, due to its positive effect on thermo regulation

Full description

Intravenous anesthetics may impair thermoregulation. Absorption of radiofrequency waves by the body surface may result in heating, especially in small children during magnetic resonance imaging (MRI). Investigators applied two different intravenous anesthetics as propofol and ketamine and studied the effect of these drugs on core body temperature.

All patients aged between 6 months-10 years were administered midazolam and atropine. After that 1 mg/ kg of propofol was applied in group I, and 0,1 ml/kg of propofol ketamine mixture ( 10 mg/ml each) was applied in group II. Core body temperatures were taken before and after MRI and compared.

Enrollment: 90 patients

Sex: All

Ages: 6 months to 10 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• children aged between 6 months-10 years,
• underwent MRI under anesthesia
• ASA I-II

Exclusion criteria

• History of drug allergy
• Severe pulmonary and cardiac disease
• Intracranial hypertension

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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90 participants in 2 patient groups

propofol

Active Comparator group

Description:

body core temperature was measured from tympanic membrane after 1 mg/kg propofol administration, before and after magnetic resonance imaging

Treatment:

Drug: Ketamine propofol mixture

Drug: propofol

ketofol

Active Comparator group

Description:

body core temperature was measured from tympanic membrane after 0,1 ml/kg administration of ketamine propofol mixture of 10 mg/ml both, before and after magnetic resonance imaging

Treatment:

Drug: Ketamine propofol mixture

Drug: propofol