Effects of Propofol and Sevoflurane on Early POCD in Elderly Patients With Metabolic Syndrome

G

General Hospital of Ningxia Medical University

Status

Completed

Conditions

Postoperative Complications

Treatments

Other: metabolic syndrome

Study type

Interventional

Funder types

Other

Identifiers

NCT02766062
NZ1651

Details and patient eligibility

About

The purpose of this study is to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

Full description

By now, a series risk factors of cardiovascular diseases, which are also related to the development of postoperative cognitive dysfunction (POCD), are becoming more common.The investigators don't know whether propofol based anesthesia has a more severe impact on early postoperative cognitive function than sevoflurane in elderly patients with metabolic syndrome. In this study, the investigators want to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

Enrollment

94 patients

Sex

All

Ages

60+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • aged ≥60 years;
  • ASAⅡor Ⅲ
  • noncardiac surgery and nonneural surgery

Exclusion criteria

  • Mini Mental State Examination [MMSE] score too low
  • chronic alcoho and drug abuse
  • disturbed renal and liver function
  • history of a cerebrovascular accident
  • permanent ventricular pacing
  • preoperative cognitive deficits
  • lack of cooperation

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

94 participants in 2 patient groups

propofol group
Active Comparator group
Description:
Patients with metabolic syndrome were randomly assigned to receive propofol anesthesia
Treatment:
Other: metabolic syndrome
sevoflurane group
Active Comparator group
Description:
Patients with metabolic syndrome were randomly assigned to receive sevoflurane anesthesia
Treatment:
Other: metabolic syndrome

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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