Effects of Propofol and Sevoflurane on Early POCD in Elderly Patients With Metabolic Syndrome

General Hospital of Ningxia Medical University

Status: Completed

Conditions: Postoperative Complications

Treatments: Other: metabolic syndrome

Study type: Interventional

Funder types: Other

Identifiers

NCT02766062

NZ1651

Details and patient eligibility

About

The purpose of this study is to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

Full description

By now, a series risk factors of cardiovascular diseases, which are also related to the development of postoperative cognitive dysfunction (POCD), are becoming more common.The investigators don't know whether propofol based anesthesia has a more severe impact on early postoperative cognitive function than sevoflurane in elderly patients with metabolic syndrome. In this study, the investigators want to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

Enrollment: 94 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged ≥60 years;
• ASAⅡor Ⅲ
• noncardiac surgery and nonneural surgery

Exclusion criteria

• Mini Mental State Examination [MMSE] score too low
• chronic alcoho and drug abuse
• disturbed renal and liver function
• history of a cerebrovascular accident
• permanent ventricular pacing
• preoperative cognitive deficits
• lack of cooperation

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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94 participants in 2 patient groups

propofol group

Active Comparator group

Description:

Patients with metabolic syndrome were randomly assigned to receive propofol anesthesia

Treatment:

Other: metabolic syndrome

sevoflurane group

Active Comparator group

Description:

Patients with metabolic syndrome were randomly assigned to receive sevoflurane anesthesia

Treatment:

Other: metabolic syndrome