Effects of Prostate Cancer on Brain Function

Tongji University

Status: Enrolling

Conditions: Prostate Cancer

Treatments: Diagnostic Test: functional magnetic resonance imaging examination、Zung Self Rating Anxiety Scale and Beck Depression Inventory-II

Study type: Observational

Funder types: Other

Identifiers

NCT05737004

EF2023-01

Details and patient eligibility

About

To explore whether the patients with prostate cancer have functional changes in specific brain areas and changes in psychological and mental characteristics compared with the patients without prostate cancer.

Full description

This study was intended to observe the functional changes of brain fMRI in patients with and without prostate cancer enrolled in the cohort of patients who planned to undergo prostate biopsy, in an attempt to discover specific brain region changes in patients with prostate cancer, and lay a foundation for further clarifying the relationship and mechanism between brain region function changes and prostate cancer.

Enrollment: 250 estimated patients

Sex: Male

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Between the ages of 18 and 80
2. Patients with prostate biopsy;
3. No history of other malignant tumors;
4. Exclude other malignant tumors;
5. Fully understand the clinical trial protocol and sign informed consent;

Exclusion criteria

1. magnetic resonance contraindications;
2. symptomatic acute or chronic inflammation of the prostate;
3. Patients with brain trauma or brain disease;
4. Patients who have died of other malignancies in the past or are currently suffering from other malignancies;
5. Patients judged by the investigator to be unfit to participate in the clinical trial;

Trial design

250 participants in 2 patient groups

Prostate cancer group

Description:

Prostate cancer was confirmed by biopsy, and fMRI examination 、Zung Self Rating Anxiety Scale and Beck Depression Inventory-II were performed in these patients within 1 week before biopsy .

Treatment:

Diagnostic Test: functional magnetic resonance imaging examination、Zung Self Rating Anxiety Scale and Beck Depression Inventory-II

Non-Prostate cancer group

Description:

Non-Prostate cancer was confirmed by biopsy, and fMRI examination 、 Zung Self Rating Anxiety Scale and Beck Depression Inventory-II were performed in these patients within 1 week before biopsy .

Treatment:

Diagnostic Test: functional magnetic resonance imaging examination、Zung Self Rating Anxiety Scale and Beck Depression Inventory-II