Effects of Protein and Fiber at Breakfast on Appetite, Blood Sugar, and Cholesterol (PFB)

Purdue University

Status: Completed

Conditions: Ingestive Behavior; Glucose Control; Brain Activity; Cholesterol; Appetite

Treatments: Other: Dietary control of protein and fiber intake at breakfast

Study type: Interventional

Funder types: Other

Identifiers

NCT02169245

1208012603

Details and patient eligibility

About

The objectives of the research are to assess the effects of increased protein and fiber intake at breakfast on neural activation in brain regions associated with appetitive drive and reward-driven eating, measures of subjective appetite, and ingestive behavior in overweight adults. Additional outcomes of interest include the effects of the breakfast intervention on blood sugar and cholesterol profiles.

Full description

The objectives of the research are to assess the effects of increased protein and fiber intake at breakfast on neural activation in brain regions associated with appetitive drive and reward-driven eating, measures of subjective appetite, and ingestive behavior in overweight adults. Additional outcomes of interest include the effects of the breakfast intervention on 24-hour glucose profile as well as fasting and postprandial glycemic and lipemic regulation. The investigators will test the effects of consuming breakfasts with normal protein/normal fiber (NPNF), normal protein/high fiber (NPHF), high protein/normal fiber (HPNF), and high protein/high fiber (HPHF) for two weeks in a randomized cross-over study.

Enrollment: 20 patients

Sex: All

Ages: 21 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male or female
• age 21 - 45 years
• BMI 25-29.9 kg/m2

Exclusion criteria

• Irregular menstrual cycles
• current smoker
• medications or supplements that affect appetite
• pregnant or lactating
• not weight stable
• acutely ill
• diabetic
• claustrophobic
• any implantation unsafe in magnetic resonance imaging (MRI) environment

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 4 patient groups

Average Protein and Fiber at Breakfast

Experimental group

Description:

Dietary control of protein and fiber intake at breakfast. Participants will eat a 400 kcal breakfast with an average amount of protein and fiber for this age group for 2 weeks.

Treatment:

Other: Dietary control of protein and fiber intake at breakfast

Average Protein and High Fiber at Breakfast

Experimental group

Description:

Dietary control of protein and fiber intake at breakfast. Participants will eat a 400 kcal breakfast with an average amount of protein and higher than average amount of fiber for this age group for 2 weeks.

Treatment:

Other: Dietary control of protein and fiber intake at breakfast

High Protein and Average Fiber at Breakfast

Experimental group

Description:

Dietary control of protein and fiber intake at breakfast. Participants will eat a 400 kcal breakfast with an average amount of fiber and higher than average amount of protein for this age group for 2 weeks.

Treatment:

Other: Dietary control of protein and fiber intake at breakfast

Higher Protein and Fiber at Breakfast

Experimental group

Description:

Dietary control of protein and fiber intake at breakfast. Participants will eat a 400 kcal breakfast with a higher than average amount of protein and fiber for this age group for 2 weeks.

Treatment:

Other: Dietary control of protein and fiber intake at breakfast